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| American Association of Tissue Banks |
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| American Association of Tissue Banks (AATB) with respect to procurement, processing, and sterilization of bone grafts. The AATB advocates excluding collection of bone under the following circumstances: |
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Donors from high-risk groups, as determined by medical testing and behavioral risk assessments |
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Donors test positive for HIV antibody by ELISA. |
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Autopsy of donor reveals occult disease. |
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Donor bone tests positive for bacterial contamination. |
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Donor and bone test positive for hepatitis B surface antigen (HbsAG) or hepatitis C virus (HCV). |
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Donor tests positive for syphilis. |
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| Using donor screening recommendations, it has been calculated that the chance of obtaining a bone graft from an HIV-infected donor (e.g., one who failed to be excluded by one of the exclusionary techniques) is one in 1.67 million [Buck 1989]. Furthermore, the probability that DFDBA might contain HIV has been calculated to be one in 2.8 billion [Russo 1995]. Therefore, the established exclusionary criteria combined with recommended processing procedures (harvesting in a sterile manner, repeated washings, immersion in ethanol, freezing in liquid nitrogen, freeze-drying, demineralization, and vacuum sealing) render DFDBA and FDBA grafts safe for human implantation. |
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| website : www.aatb.org |
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| Copyright © 2008 OsteoLife Biomedical LLC. |
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